Eurasian integration could offer a counterpoint to the EU and the United States, but only in close co-operation with states like India and China

Russia, Belarus and Kazakhstan have pursued integration with the aim of creating a Eurasian Union by 2015. David Lane writes on the economic and political background underpinning Eurasian integration and its potential to act as a counterpoint to the hegemony of the United States in the global system. He argues that while the economic weight of the three Eurasian Union states is fairly limited, pursuing close co-operation with ‘BRICS’ countries such as Brazil, India and China could offer the basis for a more pluralist and multi-polar world

Blending systems thinking approaches for organisational analysis: reviewing child protection in England

This paper concerns the innovative use of a blend of systems thinking ideas in the ‘Munro Review of Child Protection’, a high-profile examination of child protection activities in England, conducted for the Department for Education. We go ‘behind the scenes’ to describe the OR methodologies and processes employed. The circumstances that led to the Review are outlined. Three specific contributions that systems thinking made to the Review are then described. First, the systems-based analysis and visualisation of how a ‘compliance culture’ had grown up. Second the creation of a large, complex systems map of current operations and the effects of past policies on them. Third, how the map gave shape to the range of issues the Review addressed and acted as an organising framework for the systemically coherent set of recommendations made. The paper closes with an outline of the main implementation steps taken so far to create a child protection system with the critically reflective properties of a learning organisation, and methodological reflections on the benefits of systems thinking to support organisational analysis

The Burke-Gaffney Observatory: A fully roboticized remote-access observatory with a low resolution spectrograph

We describe the current state of the Burke-Gaffney Observatory (BGO) at Saint Mary's University - a unique fully roboticized remote-access observatory that allows students to carry out imaging, photometry, and spectroscopy projects remotely from anywhere in the world via a web browser or social media. Stellar spectroscopy is available with the ALPY 600 low resolution grism spectrograph equipped with a CCD detector. We describe our custom CCD spectroscopy reduction procedure written in the Python programming language and demonstrate the quality of fits of synthetic spectra computed with the ChromaStarServer (CSS) code to BGO spectra. The facility along with the accompanying Python BGO spectroscopy reduction package and the CSS spectrum synthesis code provide an accessible means for students anywhere to carry our projects at the undergraduate honours level. BGO web pages for potential observers are at the site: observatory.smu.ca/bgo-useme. All codes are available from the OpenStars www site: openstars.smu.ca/Comment: 23 pages double-spaced, 12 figures. arXiv admin note: text overlap with arXiv:2307.01279 . HR3580 now correctly identified and modelled as a giant, not a dwar

Childhood Obesity and Slipped Capital Femoral Epiphysis

We thank Emma Morely of STEPS Charity Worldwide (www.steps-charity.org.uk), the patient charity that helped direct the research agenda and will assist in the dissemination of results. We also thank the Information Services Division (ISD) of NHS Scotland for the provision of data from ISD Scotland, particularly Andrew Duffy, the research coordinator within National Services Scotland. FUNDING: Dr Perry is funded by a UK National Institute for Health Research Clinician Scientist Award (grant NIHR/CS/2014/14/012). This article presents independent research funded by the National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.Peer reviewedPostprin

Hail Disrometer Array for Launch Systems Support

Prior to launch, the space shuttle might be described as a very large thermos bottle containing substantial quantities of cryogenic fuels. Because thermal insulation is a critical design requirement, the external wall of the launch vehicle fuel tank is covered with an insulating foam layer. This foam is fragile and can be damaged by very minor impacts, such as that from small- to medium-size hail, which may go unnoticed. In May 1999, hail damage to the top of the External Tank (ET) of STS-96 required a rollback from the launch pad to the Vehicle Assembly Building (VAB) for repair of the insulating foam. Because of the potential for hail damage to the ET while exposed to the weather, a vigilant hail sentry system using impact transducers was developed as a hail damage warning system and to record and quantify hail events. The Kennedy Space Center (KSC) Hail Monitor System, a joint effort of the NASA and University Affiliated Spaceport Technology Development Contract (USTDC) Physics Labs, was first deployed for operational testing in the fall of 2006. Volunteers from the Community Collaborative Rain. Hail, and Snow Network (CoCoRaHS) in conjunction with Colorado State University were and continue to be active in testing duplicate hail monitor systems at sites in the hail prone high plains of Colorado. The KSC Hail Monitor System (HMS), consisting of three stations positioned approximately 500 ft from the launch pad and forming an approximate equilateral triangle (see Figure 1), was deployed to Pad 39B for support of STS-115. Two months later, the HMS was deployed to Pad 39A for support of STS-116. During support of STS-117 in late February 2007, an unusual hail event occurred in the immediate vicinity of the exposed space shuttle and launch pad. Hail data of this event was collected by the HMS and analyzed. Support of STS-118 revealed another important application of the hail monitor system. Ground Instrumentation personnel check the hail monitors daily when a vehicle is on the launch pad, with special attention after any storm suspected of containing hail. If no hail is recorded by the HMS, the vehicle and pad inspection team has no need to conduct a thorough inspection of the vehicle immediately following a storm. On the afternoon of July 13, 2007, hail on the ground was reported by observers at the VAB, about three miles west of Pad 39A, as well as at several other locations around Kennedy Space Center. The HMS showed no impact detections, indicating that the shuttle had not been damaged by any of the numerous hail events which occurred that day

Analysis of the March 30, 2011 Hail Event at Shuttle Launch Pad 39A

The Kennedy Space Center (KSC) Hail Monitor System, a joint effort of the NASA KSC Physics Lab and the KSC Engineering Services Contract (ESC) Applied Technology Lab, was first deployed for operational testing in the fall of 2006. Volunteers from the Community Collaborative Rain, Hail, and Snow Network (CoCoRaHS) in conjunction with Colorado State University have been instrumental in validation testing using duplicate hail monitor systems at sites in the hail prone high plains of Colorado. The KSC Hail Monitor System (HMS), consisting of three stations positioned approximately 500 ft from the launch pad and forming an approximate equilateral triangle, as shown in Figure 1, was first deployed to Pad 39B for support of STS-115. Two months later, the HMS was deployed to Pad 39A for support of STS-116. During support of STS-117 in late February 2007, an unusually intense (for Florida standards) hail event occurred in the immediate vicinity of the exposed space shuttle and launch pad. Hail data of this event was collected by the HMS and analyzed. Support of STS-118 revealed another important application of the hail monitor system. Ground Instrumentation personnel check the hail monitors daily when a vehicle is on the launch pad, with special attention after any storm suspected of containing hail. If no hail is recorded by the HMS, the vehicle and pad inspection team has no need to conduct a thorough inspection of the vehicle immediately following a storm. On the afternoon of July 13, 2007, hail on the ground was reported by observers at the Vertical Assembly Building (VAB) and Launch Control Center (LCC), about three miles west of Pad 39A, as well as at several other locations at KSC. The HMS showed no impact detections, indicating that the shuttle had not been damaged by any of the numerous hail events which occurred on that day

An Introduction to Psychological Statistics

This work has been superseded by Introduction to Statistics in the Psychological Sciences available from https://irl.umsl.edu/oer/25/. - We are constantly bombarded by information, and finding a way to filter that information in an objective way is crucial to surviving this onslaught with your sanity intact. This is what statistics, and logic we use in it, enables us to do. Through the lens of statistics, we learn to find the signal hidden in the noise when it is there and to know when an apparent trend or pattern is really just randomness. The study of statistics involves math and relies upon calculations of numbers. But it also relies heavily on how the numbers are chosen and how the statistics are interpreted. This work was created as part of the University of Missouri’s Affordable and Open Access Educational Resources Initiative (https://www.umsystem.edu/ums/aa/oer). The contents of this work have been adapted from the following Open Access Resources: Online Statistics Education: A Multimedia Course of Study (http://onlinestatbook.com/). Project Leader: David M. Lane, Rice University. Changes to the original works were made by Dr. Garett C. Foster in the Department of Psychological Sciences to tailor the text to fit the needs of the introductory statistics course for psychology majors at the University of Missouri – St. Louis. Materials from the original sources have been combined, reorganized, and added to by the current author, and any conceptual, mathematical, or typographical errors are the responsibility of the current author

A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes

Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate. One such factor is the promyelocytic leukemia (PML) protein, the nucleating and organizing factor of nuclear domain 10 (ND10). PML responds to a number of stimuli and is implicated in intrinsic and innate cellular antiviral defenses against HSV-1. While the role of PML in a number of cellular pathways is controlled by post-translational modifications, the effects of phosphorylation on its antiviral activity toward HSV-1 have been largely unexplored. Consequently, we mapped phosphorylation sites on PML, mutated these and other known phosphorylation sites on PML isoform I (PML-I), and examined their effects on a number of PML’s activities. Our results show that phosphorylation at most sites on PML-I is dispensable for the formation of ND10s and colocalization between PML-I and the HSV-1 regulatory protein, ICP0, which antagonizes PML-I function. However, inhibiting phosphorylation at sites near the SUMO-interaction motif (SIM) of PML-I impairs its ability to respond to HSV-1 infection. Overall, our data suggest that PML phosphorylation regulates its antiviral activity against HSV-1